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"Potent" weight gain pills typically refer to prescription medications used for specific medical conditions causing unwanted weight loss (cachexia or "wasting syndrome"), or over-the-counter (OTC) supplements that boost appetite and calorie intake. 

Always consult with a healthcare professional before starting any weight gain medication or supplement to determine the appropriate and safest method for your individual health needs. Unsupervised use can have significant side effects. 

Prescription Medications

Prescription-strength options are generally powerful appetite stimulants (orexigenics) used to manage severe, unintentional weight loss associated with conditions like cancer and HIV/AIDS. They work by increasing appetite or promoting muscle growth, but carry risks. 

• Megestrol (Megace ES): A lab-made form of progesterone, it is FDA-approved to stimulate appetite in patients with AIDS. It is effective but can increase the risk of blood clots.
• Dronabinol (Marinol, Syndros): A lab-made version of THC (the active ingredient in cannabis), it is approved to treat appetite loss in AIDS patients and chemotherapy-induced nausea/vomiting.
• Mirtazapine (Remeron): An antidepressant sometimes used off-label as an appetite stimulant due to weight gain being a known side effect.
• Oxandrolone: An anabolic steroid previously used to promote weight gain after surgery or infection. The FDA withdrew its approval in the U.S. in June 2023 due to safety concerns, including a boxed warning about liver injury. 

Over-the-Counter (OTC) Supplements

OTC supplements usually contain natural ingredients and aim to boost appetite, slow metabolism, or provide extra calories/protein to support mass gain, often when combined with exercise. 

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